(14 customer reviews)



Moisturiser. Mature skin, post-menopausal skin, age-related moisture loss, dry, dull, thinning or delicate skin

SkinCeutical A.G.E. Interrupter, an anti-ageing skin formulation restores the appearance of elasticity and firmness to the skin. A.G.E. Interrupter is a unique treatment formulated with 4% blueberry extract, 30% Proxylane™ to help prevent the glycation process and correct severe signs of intrinsic ageing in mature skin.

Size: 48 ml

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How to use

How to use

Massage a thin, even veil into the entire face, neck, and chest once or twice daily. Use as a 2 – in – 1 corrective moisturiser.

Features & Benefits

Features & Benefits

Intrinsic aging, caused by internal factors such as hormonal shifts and metabolic slowdown, contributes greatly to skin sagging, creping, thinning, and cracking. While glucose is a vital cellular fuel, as we age and our metabolism slows, glycation causes excess glucose molecules to stick to collagen and elastin, leading to cross-linked fibers. This cross-linking forms chemical bridges between these proteins that result in advanced glycation end-products (A.G.E.). Glycated fibers become rigid, less elastic, and have reduced regenerative ability, which leads to damage such as laxity, cracking, and thinning skin. Another major contributor of intrinsic skin aging is the flattening of the dermal epidermal junction (D.E.J.). In young skin, the D.E.J. has the appearance of a mountain range that helps anchor the epidermis to the dermis, forming a network of supportive collagen fibers. As skin ages, fibers in the D.E.J., that are primarily responsible for the appearance and texture of skin. In addition, glycosaminoglycans (GAGs),  the essential molecules responsible for holding water, nutrients and modulating the extra-cellular space in the D.E.J., break down. Both glycation and GAG depletion lead to the degradation of the extra-cellular matrix and the flattening of the D.E.J., resulting in sagging, creping, and severely wrinkled skin.

A.G.E Interrupter:

1. Prevents the rigidification of collagen and elastin fibers (cross-linking of collagen: AGE’s)
2. Exhibits a pro-matrix effect – stimulating synthesis of procollagen I and III
3. Remodels tissue structure in the dermal epidermal junction (D.E.J.) and increases elasticity and thickness — as if the skin’s mattress has been re-inflated from the inside
4. Increases bound moisture in the epidermis
5. Rich, moisturizing base hydrates thin, dry, cracking skin
6. Helps to alleviate the discomfort associated with dry, aging skin

Key Ingredients

Key Ingredients

Key Ingredients:


  • This particular extract in A.G.E. Interrupter is known for its potent anti-glycation activity
  • We currently have two patents pending with this specific ingredient, including one for anti-glycation and another for MMP inhibition
  • Four percent of the extract was the level found to be most effective in clinical trial


  • This patented molecule is obtained from xylose produced from beech wood using an environmentally friendly, chemically simple and optimized synthesis process that characterizes this molecule as a “green chemistry product”
  • Proxylane™ acts like a molecular magnet attracting GAG components to reconnect and rebuild the network of fibers, proteins, and cells in the D.E.J
  • Stimulates the synthesis of procollagen I and III by fibroblasts
  • Considerably improves cohesion between the dermis and epidermis by increasing the number of anchoring filaments in the D.E.J. and rebuilding D.E.J. structure
  • Increases expression of a hyaluronic acid receptor in the epidermis
  • Proxylane™ is easily biodegradable, non-bioaccumulatable, and non-eco-toxic

Full ingredient list:

Aqua / Water / Eau, Propylene Glycol, Dimethicone, Hydroxypropyl Tetrahydropyrantriol, Cyclohexasiloxane, Isohexadecane, Glycerin, Synthetic Wax, Dimethicone/Peg-10/15 Crosspolymer, Aluminum Starch Octenylsuccinate, Ci 77163 / Bismuth Oxychloride, Phenoxyethanol, Magnesium Sulfate, Ethylhexyl Hydroxystearate, Salicyloyl Phytosphingosine, Acrylates Copolymer, Methylparaben, Ethylparaben, Disodium Edta, Vaccinium Myrtillus Extract / Vaccinium Myrtillus Fruit Extract, Parfum / Fragrance, Butylphenyl Methylpropional, Coumarin.

Reviews (14)

14 reviews for SKINCEUTICALS A.G.E. Interrupter

  1. Michelle (verified owner)

    I am absolutely in love with this cream. It has only been a few days using it but it leaves my skin soft and very hydrated and nourished. It melts into my skin and only a little bit needed to cover my face and neck. Wonderful cream! Will definitely repurchase.

  2. Bianca (verified owner)

    This anti-ageing skin formulation restored the appearance of my skin within a few weeks of using it! I was really impressed by the results and how plump and moisturised my skin felt!

  3. Trusha (verified owner)

    Excellent product. I use this product day and night. Love the feel and texture

  4. Capetown1 (verified owner)

    Restores skin barrier while plumping and hydrating skin.
    My go to fix for tired and dehydrated skin.
    Lovely soothing product.

  5. Bianca (verified owner)

    I use this cream day and night. It melts into the skin and the product has a soft mousse texture. This cream give me the added moisture that I need.

  6. Kristen (verified owner)

    Great product. I use this at night, it’s a light product and helps with moisture.

  7. Melissa (verified owner)

    I really love this as a night cream for anti-ageing. I can see a difference in my skin. Plumper, glowing, helps with wrinkles. Worth the buy!

  8. Meagan (verified owner)

    This is the second time I have purchased this cream, I use it at night and it has repaired my skin barrier. It is pricey, but a little goes a long way and it lasts for about 3 months!

  9. Safiyya (verified owner)

    All I can say my favorite
    You simply have to try it
    Anti aging & glow

  10. Marinda66 (verified owner)

    Love it! My skin feels so smooth and looks healthy

  11. Anél (verified owner)

    Love this product. I use it only as a night cream and don’t need to put on anything else in the morning.

  12. jcstauch (verified owner)

    If I could afford this every time, I would never buy anything else.
    This particular product has 3 potent ingredients that reduce sagging, creping and thinning of skin. It really does increase elasticity and thickness of skin. It really works and my skin feels like liquid velvet after use.

  13. Lesley

    I started using this at night about 2 months ago and can definitely feel the difference, smoother plumper skin, worth the investment!


    This formula is thicker and richer than the daily moisture and as such I tend to use mine as a night cream.
    The tiniest amount (three tiny dabs, one on each cheek and one on my forehead) covers my entire face and if I use more it won’t absorb.
    When used correctly it spreads alot and leaves skin silky soft
    I have seen a marked improvement in my skin since using this, esp the tiny lines around my eyes and the fine lines caused by dehydration have disappeared.
    Even with my acne prone skin when used as a night product once a day this product does not break me out

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Delivered to your door within 1-2 working days after payment is confirmed with Standard Delivery.

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Delivered to your door within 3-5 working days after payment is confirmed with Standard Delivery.

Remote Area

Delivered to your door within 5-7 working days after payment is confirmed with Standard Delivery.

Delivery Options

  • FREE Delivery: On orders above R 750.00
  • Delivery Fee R120.00: On orders below R 750
  • I want to collect? - Collections welcome at our Pretoria office.


Main Centres: Johannesburg, Cape Town, Pretoria.
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