(38 customer reviews)



Serum. Hyperpigmentation, erythema, uneven skin tone.

Phloretin CFis an antioxidant serum that delivers environmental protection while diminishing the appearance of discolouration. Ideal if you want your skin shielded from free radicals for a more radiant, even complexion

Size: 30 ml

We are expecting Phloretin CF to arrive from SkinCeuticals USA at the end of February. If necessary please contact our skincare therapists on live chat to find a suitable alternative in the meantime.

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Skin results and statements are based on clinical trials performed by the brand and individual results may vary.



How to use

How to use

Once daily, in the morning, apply directly after cleanse and tone. Using fingertips, apply 4-5 drops of Phloretin CF to face, neck, and chest. Follow with application of your recommended corrective product, moisturiser and SPF.

Features & Benefits

Features & Benefits

Derived from apples and the root bark of fruit trees including apple, pear, and grapefruit, Phloretin is a broad- spectrum molecule newly identified for its antioxidant properties and recently studied for use as a pigment- regulating and penetration-enhancing agent in the medical community. Additionally, it displays a wide range of bioactivities such as anticancer, antifungal, antibacterial, antiviral, and anti-inflammatory.

Phloretin CF™ represents a new class of preventive and corrective topical antioxidant treatment. This patent- pending breakthrough technology combines the broad-range power of Phloretin with vitamin C and Ferulic acid in a synergistic biodiverse formulation to divide and conquer sources of damage at every level of the skin.

Phloretin CF™ is a broad-spectrum treatment that protects  against not only free radicals,  but the range of other reactive molecules known  to cause damage and DNA mutations among the integral cell types.

Effect of vitamin C, ferulic acid, and phloretin (CFerPhlor) protection against ultraviolet (UV)-induced erythema. CFerPhlor or vehicle alone (control) were applied to back skin (2 mg/cm2) daily for 4 days. Skin was irradiated with solar-simulated UV 1×–5× minimal erythema dose (MED). Erythema was determined 1 day later.


For over a decade, SkinCeuticals has offered a variety of antioxidant treatments to combat environmental damage caused by reactive oxygen species.

Through continuous research and development, we strive to provide the most comprehensive solution to prevent and correct photodamage caused by oxidative stress. Phloretin CF:

  1. Prevents premature signs of aging
  2. Corrects existing photo damage, especially age spots
  3. Facilitates cellular repair
  4. Reconstructs the skin’s support structure.



Key Ingredients

Key Ingredients

Key Ingredients:


  • The body’s most important water-soluble antioxidant
  • Inhibits UVA and UVB radiation-induced damage
  • Photo protective capabilities
  • Promotes collagen synthesis
  • Anti-inflammatory properties


  • Comes from apples and the root bark of fruit trees including apple, pear, and grapefruit
  • Classified as a flavonoid known to prevent immunosuppression and for anti-inflammatory, antifungal, and anticancer properties
  • Accelerates cell turnover
  • Suppresses radiation-induced oxidative reactions
  • Slows the degradation of collagen
  • Increases the production of elastin
  • Maintains the integrity of the extra cellular matrix
  • Inhibits UV-induced melanogenesis


  • Ubiquitous plant antioxidant
  • Neutralizes free radicals known as “superoxide,” “hydroxyl radical” and “nitric oxide”
  • Suppresses radiation-induced oxidative reactions
  • Acts synergistically with other antioxidants, improving their potency
  • Absorbs UV (approved sunscreen in japan)
  • Anti-inflammatory properties
  • Easily absorbed by the skin

Full ingredient list:

Aqua / Water / Eau, Dipropylene Glycol, Alcohol Denat., Ascorbic Acid, Butylene Glycol, Triethyl Citrate, Phloretin, Ferulic Acid.

Reviews (38)

38 reviews for SKINCEUTICALS Phloretin CF

  1. Jack (verified owner)

    I alternate this with the CE Ferulic. The aforementioned remains my Vitamin C-best but this does bring a certain refining aspect especially in the warmer months.

  2. Sascha (verified owner)

    I use CE Ferulic but decided a change up in order as winter coming and I am glad I did – (I do like to switch up my serums every now and again.) As with Skinceuticals products its a first class serum in fact I have noticed more so with this serum than with CE that some of my sun spots are milder in appearance which is great, and this is after a month and it does keep my skin hydrated .

  3. Claire (verified owner)

    My absolute favourite serum from the brand. If you are going to invest in one serum to treat pigmentation, this is it! I have a sensitive to dry skin and my skin loves this serum!

  4. DerryAnn

    Received this product as a gift with purchase. It is definitely one of the best vitamin c serums I have used. The results speak for themselves. I have noticed a definite improvement in my pigmentation and my skin is a lot brighter.

  5. Haseena (verified owner)

    I received a sample vial of this 3 years ago and fell in love with it- the price gave me pause but I think it’s worth the splurge, mostly, so using my miles along with Black Friday deals, I finally added to cart. I have acne-prone slightly textured combination skin, with the start of very fine horizontal lines on my forehead. Been using it for a month now, 3-4 times a week. This serum makes my skin feel and appear smoother, and brighter, all things I love. And because I don’t have dry skin and it’s hot the routine is simple: LRP or NeoStrata cleanser – 4-5 drops Phloretin CF face and neck – Heliocare SPF. The glow is real!

  6. Yuri (verified owner)

    This is my second bottle and loving it. My skin in visibly brighter when I apply the product. I am getting a little rash with this round, but I may just need to adjust.

  7. Tsholofelo (verified owner)

    This serum was recommended by the doctor after I did my skin assessment. At first I was skeptical of buying such an expensive little bottle to deal with my pigmentation, since every brand claims to even out uneven tone whilst in fact they don’t. But wooah with this I’m blown away, first time in so many years I’ve actually seen a product work for my uneven skin. Definitely love this product and I will keep it in my skin routine product for ever and ever.

  8. Zeruiah (verified owner)

    2nd bottle that I’ve bought. I’ve always had pigmentation once a pimple heals and this literally helps lighten my marks much faster then any previous product I have ever used.

  9. Ashleigh (verified owner)

    The best antioxidant around that I honestly just can’t live without. However, my only complaint continues to be the bottle that leaks when travelling – such a waste as it is like liquid gold, and such a pity to have to travel without it.

  10. Jurette (verified owner)

    Best serum for hyperpigmentation.

  11. Karmisha (verified owner)

    Great product especially with Indian skin as some are prone to pigmentation..

  12. Cindy

    Received this as a free bee when I order another product. Was so so impressed, haven’t found anything that’s made my skin look more brighter and smooth.

  13. Kristen (verified owner)

    Best product I’ve used for pigmentation and uneven skin tone, couldn’t recommend it more!

  14. Karoshia (verified owner)

    This product is the best for my pigmentation. Lightened it quite a big. Love it, love it, love it

  15. Zanele (verified owner)

    The best antioxidant serum ever but with my recent purchase it has became so strong for me I developed rash but I’ll go back to it again.

  16. Janine (verified owner)

    So far so good, I have been using this for only two weeks but it leaves my skin soft, glowing and has already made a difference to pigment!

  17. Linda (verified owner)

    A dermatologist recommended this product about 3 years ago and I have since not stopped using it. If there is one product that works this is it. I had gone for a skin analysis No pigmentation, no photoaging, etc.

  18. Sumayya (verified owner)

    Just started using this product and already loving the clarity n glow it’s giving

  19. Deidre (verified owner)

    I absolutely love this product. It feels light and a little goes a long way. My skin looks brighter, and fresher, since I have started using it. It’s pricey, but well worth it.

  20. Zamahlase (verified owner)

    I have finally found the ONE!!

    Phloretin CF has done wonders for my oily acne prone skin with blemishes. I also noticed that my face no longer breakout like before. My face is clear, brighter and smooth. I have recommended it to a friend with a similar skin as mine.

    It has really brought back confidence in me.

  21. Yuri (verified owner)

    I have sensitive skin and was worried when I purchased this product after it was recommended by my doctor. I have bee using it for 2 weeks already and I have not had any adverse reactions! My skin instead looks brighter, softer and hydrated! This is really liquid gold!

  22. Sarita (verified owner)

    If I ever have to choose only 1 product, this would be the one. I spend a lot of time outdoors and have freckle prone skin. Nothing works for me like Phloretin CF does for this specific concern. It is a brilliant product overall and does so much to leave my skin looking and feeling great. In winter I switch to CE Ferulic for additional hydration, but I definitely get more freckly if I continue using it into summer.

  23. Ashleigh (verified owner)

    My absolute best best best product. Obviously it is expensive, but you get what you pay for and my skin is looking its best. I have tried CE Ferulic and just find that Phloretin CF suits my skin better. I have previously given this product a 5 star rating, so the ONLY reason for 4 stars this time is that I cannot travel with this product without it leaking! As it is so expensive, any wastage is heartbreaking and now, I simply can’t take it with my when I go away. For the price, I urge Skinceuticals to relook to packaging so it doesn’t leak, then it will be 100% perfect!

  24. Gillianb (verified owner)

    I have a combination skin and have used both the CE Ferulic and the Phloretin CF. I find that, in summer, the Phloretin is better for me, especially as I have a slightly oiler centre panel. Together with an eye cream, I use the Heliocare sunblock and find these work well for summer. I would probably switch back to the CE Ferulic in winter.

  25. Yanmin (verified owner)

    I have used this product for 2 weeks and my skin tone is brightened, but I need to do extra moisturizing

  26. Nadiar (verified owner)

    I have been using this product for over 2 years and the improvement in my pigmentation has been gradual but very significant. I would say it is almost cleared. I always use a high factor sunscreen. The active ingredients are concentrated so one bottle can last a year if not longer. I would highly recommend this product.

  27. Karoshia (verified owner)

    This product improved my pigmentation significantly. I used the ferulic acid previously but I did find that the Phloretin CF was far more effective than the ferulic for my skin.

  28. Palesa (verified owner)

    Started using this product on and off since December 2019. The pigmentation on my skin has improved dramatically and I have been receiving compliments since I started using it. It is quite an expensive product but the skin therapist I started seeing in April urged me to reconsider and use it again. My skin continues to look brighter,

  29. Rishana (verified owner)

    The product is amazing – my skin looks and feels better once I started using it. I am sure to never run out if it because my skin immediately starts to look dull when I don’t use it. A little really does go a long way.

  30. Palesa (verified owner)

    I have been using this product on and off since 2018 but consistently since April 2021. The difference in the pigmentation is noticeable and I have been receiving many compliments and how bright my skin looks.

  31. Verna

    Been trying out samples of this and I’m hoping to purchase the full bottle very very soon because the drastic change it has made to my face is so noticeable, I have never felt so confident. I experienced no irritation as well.

  32. Rochelle (verified owner)

    I’m disappointed. This product works so well for many therefore I wanted to try it out. Unfortunately it is too rich for my sensitive skin. It’s irritated my skin

  33. chris (verified owner)

    Highly effective AOX product to help shield your skin from environmental damage and target uneven skin tone. Even though I have dry skin, this works so well, with less irritation than from CE Ferulic, because it has 10% L-AA instead of 15%.

  34. Ashleigh (verified owner)

    Expensive, but definitely worth it. I have received so many compliments on my glowing skin since I started using it religiously every morning. Not sure I’ll ever be able to do without it.

  35. Zanele Masilela

    My aesthetic Dr. recommended this product to assist my skin since i have pigmentation and large pores, I was skeptical because its expensive but within a week or so I could see the benefits and brightens skins complexion so well. nothing says beautiful skin like healthy skin forget about the price tag because antioxidant and vitamin C its all the luxury your skin needs.

  36. Cleo Mbatha

    I received a sample of this product and fell in love with the results in less than a week. I decided to purchase the full size and I have been using it religiously over 2 months. A little goes a long way and I have noticed a significant improvement in the texture of my skin. My dark spots caused by Hormonal imbalance and acne is starting to lighten. You wont go wrong if you pair this with a good moisturizer and sunscreen.

  37. Ursula

    Absolutely loved this. I got it as a sample when I ordered the cleanser. I was hooked from about day 2. My skin was brighter, plumper and very radiant. I’m still accumulating enough skinmiles to spoil myself with the full sized bottle. A definite buy again ❤️

    • Dr Alek Nikolic

      Hi Ursula thank you for the review it is appreciated and will go a long way in helping customers decide if they should purchase the Phloretin CF. You may be interested in the limited edition mini Phloretin CF 15 ml which is now available to purchase. If you are interested please follow this link: Phloretin CF 15 ml Limited Edition
      Kind regards Dr Alek

  38. Sally

    The best way to keep your skin healthy and protected. I’m not sure how it works, but it works. A little goes a long way.

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